Premium
Frontispiece: Synthesis of Artemisinin‐Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action
Author(s) -
Fröhlich Tony,
Hahn Friedrich,
Belmudes Lucid,
Leidenberger Maria,
Friedrich Oliver,
Kappes Barbara,
Couté Yohann,
Marschall Manfred,
Tsogoeva Svetlana B.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201883264
Subject(s) - artemisinin , human cytomegalovirus , chemistry , computational biology , identification (biology) , virology , biology , gene , biochemistry , plasmodium falciparum , immunology , malaria , botany
The targets of artemisinin and the precise mechanisms underlying the antimalarial, anticancer, and antiviral activities are still not fully understood. Immobilization of new artemisinin‐based di‐ and trimers and application for mass spectrometry‐based target‐“fishing” experiments with total lysates of human cytomegalovirus (HCMV)‐infected human foreskin fibroblasts was performed for the first time. This resulted in identification of two putatively compound‐binding viral proteins, which are both essential for HCMV replication. For more information, see the Full Paper by M. Marschall, S. B. Tsogoeva et al. on page 8103 ff.