Premium
Frontispiece: N‐Terminal Cu‐Binding Motifs (Xxx‐Zzz‐His, Xxx‐His) and Their Derivatives: Chemistry, Biology and Medicinal Applications
Author(s) -
Gonzalez Paulina,
Bossak Karolina,
Stefaniak Ewelina,
Hureau Christelle,
Raibaut Laurent,
Bal Wojciech,
Faller Peter
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201883262
Subject(s) - chemistry , amino acid , metalloprotein , biochemistry , chemical biology , scope (computer science) , computational biology , combinatorial chemistry , biology , computer science , enzyme , programming language
Engineering a copper site into proteins or peptides can add new functions to them. Two very small and relatively strong Cu II binding sites consist of two or three amino acids at the N‐terminus. They can be easily added chemically or recombinantly. Such constructs have been used in metalloprotein engineering for different approaches in chemistry, biology and medicine. Recent developments, scope and limits of these motifs for medical and biological applications are summarized on page 8029 ff.