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Frontispiece: Interrogating Protein Phosphatases with Chemical Activity Probes
Author(s) -
Casey Garrett R.,
Stains Cliff I.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201883163
Subject(s) - phosphatase , kinase , biochemistry , enzyme , phosphorylation , protein phosphorylation , protein kinase a , chemistry , microbiology and biotechnology , biology
The activities of protein phosphatases and protein kinases are responsible for maintaining the phosphoproteome. Although protein kinases have long enjoyed the spotlight, protein phosphatases have more recently been recognized as important signaling enzymes in both normal and disease physiology. This Minireview aims to highlight advances and opportunities for the development of chemical activity probes for protein phosphatases. For more details, see G. R. Casey and C. I. Stains on page 7810 ff.