Premium
Frontispiece: Trans‐Metal‐Trapping: Concealed Crossover Complexes En Route to Transmetallation?
Author(s) -
Uzelac Marina,
Mulvey Robert E.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201883161
Subject(s) - transmetalation , bimetallic strip , electrophile , chemistry , surface modification , trapping , combinatorial chemistry , cooperativity , metal , group 2 organometallic chemistry , organometallic chemistry , molecule , polymer chemistry , organic chemistry , catalysis , ecology , biology , biochemistry
Lithiation of organic substrates remains a widely utilized reaction in synthesis. However, when substrates are heteroaromatic or contain electrophilic substituents, the lithiated intermediates can sometimes decompose and be lost for onward functionalization. By adding an organometallic (Al or Ga) trap that captures the whole molecule including Li, the stability of these sensitive intermediates can be improved through bimetallic cooperativity to transform failed lithiations into successful metallations. See more in the Concept article by Uzelac and Mulvey on page 7786 ff.