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Frontispiece: Synthesis and HNO Donating Properties of the Piloty's Acid Analogue Trifluoromethanesulphonylhydroxamic Acid: Evidence for Quantitative Release of HNO at Neutral pH Conditions
Author(s) -
Adas Sonya K.,
Bharadwaj Vinay,
Zhou Yang,
Zhang Jiuhong,
Seed Alexander J.,
Brasch Nicola E.,
Sampson Paul
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201882964
Subject(s) - nitroxyl , chemistry , molecule , inorganic chemistry , nitric acid , organic chemistry
Molecules which spontaneously release HNO (nitroxyl) are currently of much interest, since the biological activity of HNO differs from NO; HNO shows promise in treating heart failure. The synthesis and characterization of the simple HNO donor molecule CF 3 SO 2 NHOH is presented. Unlike other aliphatic analogues of the established HNO donor Piloty's acid, CF 3 SO 2 NHOH spontaneously decomposes to release HNO under neutral pH conditions. For more information, see the Communication by N. E. Brasch, P. Sampson, et al. on page 7330 ff.