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Frontispiece: On the Antibacterial Activity of Azacarboxylate Ligands: Lowered Metal Ion Affinities for Bis‐amide Derivatives of EDTA do not mean Reduced Activity
Author(s) -
Mulla Raminder S.,
Beecroft Marikka S.,
Pal Robert,
Aguilar Juan A.,
PitarchJarque Javier,
GarcíaEspaña Enrique,
LurieLuke Elena,
Sharples Gary J.,
Gareth Williams J. A.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201882864
Subject(s) - amide , affinities , chelation , chemistry , mutant , metal , binding affinities , metal ions in aqueous solution , bacteria , stereochemistry , combinatorial chemistry , antibacterial activity , biochemistry , nuclear chemistry , inorganic chemistry , biology , organic chemistry , gene , receptor , genetics
Chelating ligands such as EDTA are widely added to consumer products for preservation enhancement. They inhibit the growth of bacteria and other microorganisms by interfering with the uptake and usage of essential metal ions, though the precise mechanisms by which they do so aren't well understood. Two di‐amide derivatives of EDTA are prepared and characterised in this study that feature additional ligating groups in the pendent amide arms. Under some conditions, these ligands reveal superior bacteriostatic activity to EDTA, despite being less avid binders of common bio‐relevant metal ions. Minimum inhibitory concentrations (MIC), at which they exert bacteriostatic effects, do not necessarily correlate with log K values for metal ion binding, challenging the conventional wisdom. Growth inhibition on mutant E. coli strains with defective outer‐membrane lipopolysaccharide structures is assessed to provide insight into the unexpected behaviour. For more details, see the Full Paper by J. A. Gareth Williams et al. on page 7137 ff.