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Frontispiece: Synthetic Glycans and Glycomimetics: A Promising Alternative to Natural Polysaccharides
Author(s) -
Zhang GaoLan,
Ye XinShan
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201882663
Subject(s) - glycan , polysaccharide , chemistry , heparin , biochemistry , homogeneous , conjugate , computational biology , biology , glycoprotein , mathematical analysis , mathematics , physics , thermodynamics
Naturally extracted polysaccharide–protein conjugates and heparin are commonly used therapeutics in clinical trials. Specifically, one is from bacteria fermentation, the other is from animal tissues such as porcine mucosa. The natural polysaccharide structure is heterogeneous and the quality is inconsistent. In comparison, synthetic glycans are structurally homogeneous with controllable quality. Synthetic glycan conjugates, heparin‐related therapeutics, and glycomimetics continue to be developed. For more information, see the Minireview by G.‐L. Zhang and X.‐S. Ye on page 6696 ff.