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Frontispiece: Inhibitor‐Directed Spin Labelling—A High Precision and Minimally Invasive Technique to Study the Conformation of Proteins in Solution
Author(s) -
Yin Dongsheng M.,
Hammler Daniel,
Peter Martin F.,
Marx Andreas,
Schmitz Anton,
Hagelueken Gregor
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201882661
Subject(s) - macromolecule , labelling , diamagnetism , site directed spin labeling , chemistry , biophysics , computational biology , crystallography , physics , biochemistry , biology , quantum mechanics , membrane , magnetic field
A label hits the target. This allows measurement of distance distributions within macromolecules or macromolecular complexes. It can be applied in solution, in lipid environments, or even in cells. Because most biological macromolecules are diamagnetic, they are normally invisible for this type of spectroscopy. Read more about this technique in the Concept article by Hagelueken and coworkers on page 6665 ff.