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Frontispiece: Three‐Component Domino Knoevenagel/Vinylogous Michael Reaction: Entry to Challenging o ‐Terphenyls
Author(s) -
Grau Dominik,
Grau Benedikt W.,
Hampel Frank,
Tsogoeva Svetlana B.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201882564
Subject(s) - domino , knoevenagel condensation , malononitrile , michael reaction , component (thermodynamics) , chemistry , cascade reaction , combinatorial chemistry , organic chemistry , catalysis , physics , thermodynamics
Combination of a novel organocatalytic three‐component two‐step domino reaction with a subsequent new three‐step domino process, starting from easily accessible nitroolefins, malononitrile, and arylacetaldehydes, allows an unprecedented easy access to challenging highly functionalized o ‐terphenyls, which are of high interest for materials science and medicinal chemistry. For more information, see the Full Paper by S. B. Tsogoeva and co‐workers on page 6551 ff.