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Frontispiece: Disulfide‐Linked Dendritic Oligomeric Phthalocyanines as Glutathione‐Responsive Photosensitizers for Photodynamic Therapy
Author(s) -
Chow Sun Y. S.,
Wong Roy C. H.,
Zhao Shirui,
Lo PuiChi,
Ng Dennis K. P.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201882265
Subject(s) - singlet oxygen , photodynamic therapy , phthalocyanine , glutathione , chemistry , disulfide bond , fluorescence , photochemistry , photosensitizer , molecule , cleavage (geology) , glutathione disulfide , oxygen , biochemistry , materials science , organic chemistry , physics , quantum mechanics , fracture (geology) , composite material , enzyme
A series of disulfide‐linked dendritic phthalocyanines were synthesized. Having 2 to 6 zinc(II) phthalocyanine units in a molecule, these compounds were significantly self‐quenched. Upon interaction with glutathione (GSH), the fluorescence intensity of and singlet oxygen generation by these compounds could be restored both in citrate solution and inside HT29 cells as a result of cleavage of the disulfide linkages and separation of the phthalocyanine units. Upon irradiation, these compounds were photocytotoxic. An intravenous injection of the hexameric analogue into tumor‐bearing nude mice led to activation of the compound and increase in fluorescence intensity at the tumor site. More information can be found in the Full Paper by Dennis K. P. Ng et al. on page 5779 ff.