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Frontispiece: Chemistry and Biology of Teixobactin
Author(s) -
Guo Chuchu,
Mandalapu Dhanaraju,
Ji Xinjian,
Gao Jiangtao,
Zhang Qi
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201882162
Subject(s) - lipid ii , peptidoglycan , teichoic acid , biochemistry , chemistry , biology , stereochemistry , cell wall
Teixobactin targets both the peptidoglycan precursor lipid II, and the wall teichoic acid precursor lipid III, hence representing a highly promising lead compound in the fight against antimicrobial resistance. In their Review on page 5406 ff., J. Gao, Q. Zhang et al. discuss many aspects of teixobactin, including biological activity, biosynthetic pathway, mode of action, and the structure–activity relationships.