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Frontispiece: ortho ‐Quinones and Analogues Thereof: Highly Reactive Intermediates for Fast and Selective Biofunctionalization
Author(s) -
Bruins Jorick J.,
Albada Bauke,
van Delft Floris
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201881962
Subject(s) - surface modification , conjugate , cycloaddition , reactive intermediate , chemistry , reactivity (psychology) , combinatorial chemistry , oligonucleotide , phenols , bioconjugation , organic chemistry , catalysis , biochemistry , medicine , dna , mathematical analysis , alternative medicine , mathematics , pathology
Ortho ‐quinones , generated in situ by oxidation of catechols or phenols, are highly reactive cyclic structures with a unique reactivity profile. In particular, ortho ‐quinones readily undergo Michael addition or Diels–Alder cycloaddition, thereby enabling fast and selective functionalization. In this Mireview by F. van Delft et al. on page 4749 ff., a comprehensive summary is provided of chemistry based on ortho‐quinones, thereby enabling the preparation of conjugates of oligonucleotides and/or proteins. Applications of the biomolecular conjugates are found in surface modification and protein functionalization.