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Frontispiece: Cobalt‐Catalyzed Asymmetric Allylation of Cyclic Ketimines
Author(s) -
Wu Liang,
Shao Qihang,
Yang Guoqiang,
Zhang Wanbin
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201880663
Subject(s) - enantioselective synthesis , catalysis , oxazoline , cobalt , transition metal , ligand (biochemistry) , chemistry , potassium , metal , zhàng , combinatorial chemistry , medicinal chemistry , organic chemistry , receptor , biochemistry , political science , law , china
Utilizing the more economical and abundant late first‐row transition‐metal catalysts is a strong tendency for sustainable chemical synthesis. A Co II ‐catalyzed enantioselective addition of potassium allyltrifluoroborate to cyclic ketimines was developed, providing the corresponding chiral α‐tertiary amines in high yields and with good enantioselectivities. The chiral Ph‐substituted bis(oxazoline) ligand is crucial for the success of this asymmetric addition reaction. For more information, see the Communication by G. Yang, W. Zhang et al. on page 1241 ff.