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Frontispiece: Asymmetric Aminalization via Cation‐Binding Catalysis
Author(s) -
Park Sang Yeon,
Liu Yidong,
Oh Joong Suk,
Kweon Yoo Kyung,
Jeong Yong Bok,
Duan Mengying,
Tan Yu,
Lee JiWoong,
Yan Hailong,
Song Choong Eui
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201880563
Subject(s) - enantiopure drug , enantioselective synthesis , catalysis , aminal , chemistry , derivatization , combinatorial chemistry , phthalimides , organic chemistry , phthalimide , high performance liquid chromatography
Cation‐binding catalysis using Song's chiral OligoEG catalyst enables, for the first time, a highly enantioselective aminal formation reaction from aliphatic α‐amido sulfones as in‐situ equivalents of imines with potassium phthalimides. Derivatization of enantioenriched aminals were also realized, showing the unprecedented application potential of the enantiopure aminals in asymmetric syntheses of natural products and biologically active molecules. For more details, see the Communication by C. E. Song et al. on page 1020 ff.