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Frontispiece: Structure and Function of Human Tyrosinase and Tyrosinase‐Related Proteins
Author(s) -
Lai Xuelei,
Wichers Harry J.,
SolerLopez Montserrat,
Dijkstra Bauke W.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201880164
Subject(s) - tyrosinase , albinism , melanin , melanosome , biology , function (biology) , enzyme , biochemistry , chemistry , genetics
Melanin is key for the pigmentation of skin, hair and eyes in mammals. Tyrosinases are melanogenic metalloenzymes whose molecular mechanisms are largely unknown. Difficulties with producing these enzymes in pure form have hampered the understanding of their activity and their implication in albinism and pigmentation disorders. The first crystal structure of a human tyrosinase family member (TYRP1), sheds light on the intricate process of melanogenesis, unveils the structure–function relationship of albinism‐causing mutations, and may guide novel therapeutics for pigmentation disorders and melanoma formation. For more details see the Minireview article by B. W. Dijkstra et al. on page 47 ff.