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Simple Endotoxin Detection Using Polymyxin‐B‐Gated Nanoparticles
Author(s) -
Otri Ismael,
El Sayed Sameh,
Medaglia Serena,
MartínezMáñez Ramón,
Aznar Elena,
Sancenón Félix
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201806306
Subject(s) - nanodevice , rhodamine b , detection limit , polymyxin b , polymyxin , cationic polymerization , nanoparticle , aqueous solution , mesoporous silica , peptide , nanotechnology , materials science , chemistry , combinatorial chemistry , mesoporous material , chromatography , biochemistry , organic chemistry , antibiotics , catalysis , photocatalysis
A nanodevice based on mesoporous silica nanoparticles with rhodamine B in the pore framework, functionalized with carboxylates on the outer surface and capped with the cationic polymyxin B peptide, was used to selectively detect endotoxin in aqueous solutions with a limit of detection in the picomolar range.