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Cover Feature: Iridium(III) Complex‐Based Activatable Probe for Phosphorescent/Time‐Gated Luminescent Sensing and Imaging of Cysteine in Mitochondria of Live Cells and Animals (Chem. Eur. J. 6/2019)
Author(s) -
Du Zhongbo,
Zhang Run,
Song Bo,
Zhang Wenzhu,
Wang YongLei,
Liu Jianping,
Liu Chaolong,
Xu Zhi Ping,
Yuan Jingli
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201806287
Subject(s) - iridium , cysteine , phosphorescence , luminescence , in vivo , chemistry , luminescent measurements , fluorescence , stokes shift , ruthenium , photochemistry , biophysics , materials science , biochemistry , biology , enzyme , optoelectronics , physics , catalysis , microbiology and biotechnology , quantum mechanics
An activatable iridium(III) complex probe for phosphorescence/time‐gated luminescence detection of cysteine (Cys) in vitro and in vivo is reported. The probe, [Ir(ppy) 2 (NTY‐bpy)][(PF 6 )] features large Stokes shift, long‐lived emission, good biocompatibility, high sensitivity and selectivity for Cys detection. Compound [Ir(ppy) 2 (NTY‐bpy)][(PF 6 )] is mitochondria targetable, which makes it convenient for the determination of Cys‐mediated redox activities in mitochondria. In vivo sensing and imaging of Cys in D. magna , zebrafish, and mice are demonstrated. More information can be found in the Full Paper by R. Zhang, W. Zhang, J. Yuan et al. on page 1498.