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Co I ‐Catalyzed Barbier Reactions of Aromatic Halides with Aromatic Aldehydes and Imines
Author(s) -
Presset Marc,
Paul Jérôme,
Cherif Ghania Nait,
Ratnam Nisanthan,
Laloi Nicolas,
Léonel Eric,
Gosmini Corinne,
Le Gall Erwan
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201806239
Subject(s) - halide , catalysis , chemistry , aromaticity , organic chemistry , electrophilic aromatic substitution , medicinal chemistry , molecule
The reductive Barbier coupling of aromatic halides and electrophiles has been achieved using a CoBr 2 /1,10‐phenanthroline catalytic system and over stoichiometric amounts of zinc. The reaction displayed a broad scope of substrates, including (hetero)aryl chlorides as pro‐nucleophiles and aldehydes or imines as electrophiles, leading to diarylmethanols and diarylmethylamines in moderate to excellent yields, respectively.