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Alkylation of Allyl/Alkenyl Sulfones by Deoxygenation of Alkoxyl Radicals
Author(s) -
Han JiaBin,
Guo Ao,
Tang XiangYing
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201806138
Subject(s) - deoxygenation , radical , chemistry , alkoxy group , reagent , photochemistry , alkylation , organic chemistry , catalysis , alkyl
A challenging deoxygenation of alkoxyl radicals from readily accessible alcohol derivatives was developed, affording facile synthesis of functionalized alkenes with good functional group tolerance under mild reaction conditions. Because alkoxyl radicals can easily undergo β‐fragmentations or hydrogen abstractions, this new strategy for deoxygenation of alkoxyl radicals is highly valuable. Moreover, mechanistic studies revealed that the electron‐neutral phosphine acts as the deoxygenation reagent.