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Electrochemical and Scalable Dehydrogenative C(sp 3 )−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow
Author(s) -
Nikolaienko Pavlo,
Jentsch Marc,
Kale Ajit P.,
Cai Yunfei,
Rueping Magnus
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201806092
Subject(s) - electrochemistry , amination , continuous flow , scalability , hydrogen atom , transfer (computing) , chemistry , hydrogen , computer science , physics , database , catalysis , organic chemistry , operating system , electrode , mechanics , alkyl
A hydrogen atom transfer‐directed electrochemical intramolecular C−H amination has been developed in which the N‐radical species are generated at the anode, and the base required for the reaction is generated at the cathode. A broad range of valuable pyrrolidines were prepared in good yields and with high chemoselectivity. The reaction was easily scaled up in both batch and continuous flow systems.