Premium
Cover Feature: Interaction of Functionalized Naphthalenophanes with Abasic Sites in DNA: DNA Cleavage, DNA Cleavage Inhibition, and Formation of Ligand–DNA Adducts (Chem. Eur. J. 8/2019)
Author(s) -
Caron Coralie,
Duong Xuan N. T.,
Guillot Régis,
Bombard Sophie,
Granzhan Anton
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201806037
Subject(s) - chemistry , dna , cleavage (geology) , adduct , ap site , ligand (biochemistry) , stereochemistry , cationic polymerization , biochemistry , dna damage , biology , polymer chemistry , receptor , organic chemistry , paleontology , fracture (geology)
Cationic naphthalenophanes represent a family of small‐molecule ligands that bind with high affinity and selectivity to abasic (AP) sites in double‐stranded DNA. Depending on the functional groups present in the naphthalenophane scaffold, this process may lead to efficient indirect inhibition of enzymatic (APE1) hydrolysis of AP sites, ligand‐induced DNA cleavage via a β‐elimination mechanism, or formation of covalent ligand—DNA adducts. More information can be found in the Full Paper by A. Granzhan et al. on page 1949. The image was produced by Frank McKenna with UCSF Chimera.