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Mo‐Based Oxidizers as Powerful Tools for the Synthesis of Thia‐ and Selenaheterocycles
Author(s) -
Franzmann Peter,
Beil Sebastian B.,
Schollmeyer Dieter,
Waldvogel Siegfried R.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201805938
Subject(s) - electrophile , intramolecular force , alkyl , halide , disulfide bond , chemistry , combinatorial chemistry , diselenide , stereochemistry , organic chemistry , catalysis , selenium , biochemistry
A highly efficient synthetic protocol for the synthesis of thia‐ and selenaheterocycles has been developed. By employing a MoCl 5 ‐mediated intramolecular dehydrogenative coupling reaction, a broad variety of structural motifs was isolated in yields up to 94 %. The electrophilic key transformation is tolerated by several labile moieties like halides and tertiary alkyl groups. Due to the use of disulfide or diselenide precursors, a high atom efficiency was achieved.