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Cu‐Catalyzed Desulfonylative Amination of Benzhydryl Sulfones
Author(s) -
Nambo Masakazu,
Tahara Yasuyo,
Yim Jacky C.H.,
Crudden Cathleen M.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201805638
Subject(s) - amination , sulfone , intramolecular force , catalysis , substrate (aquarium) , chemistry , combinatorial chemistry , carbene , organic chemistry , oceanography , geology
A new method for the synthesis of benzhydryl amines from the reaction of readily available sulfone derivatives with amines is described. The Cu‐catalyzed desulfonylative amination not only provides structurally diverse benzhydryl amines in good yields, but is also applicable to iterative and intramolecular aminations. Control experiments suggested that the formation of a Cu‐carbene intermediate generated from the sulfone substrate, which represents a new route for desulfonylative transformations.