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Cover Feature: Synthesis of the Core Oligosaccharides of Lipooligosaccharides from Campylobacter jejuni : A Putative Cause of Guillain–Barré Syndrome (Chem. Eur. J. 3/2019)
Author(s) -
Yoshida Fumi,
Yoshinaka Hiroki,
Tanaka Hidenori,
Hanashima Shinya,
Yamaguchi Yoshiki,
Ishihara Mikio,
Saburomaru Miyuki,
Kato Yuki,
Saito Risa,
Ando Hiromune,
Kiso Makoto,
Imamura Akihiro,
Ishida Hideharu
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201805524
Subject(s) - campylobacter jejuni , ganglioside , guillain barre syndrome , molecular mimicry , antibody , pathogenesis , microbiology and biotechnology , biology , immunology , bacteria , biochemistry , genetics
This artwork represents a putative event in Guillain–Barré syndrome (GBS) pathogenesis based on molecular mimicry between microbial lipooligosaccharides (LOS) and human peripheral nerve gangliosides. IgG antibodies produced against ganglioside‐like LOSs on bacterial surfaces attack mammalian gangliosides expressed at the node of Ranvier, leading to the onset of GBS causing axonal neuropathy. More information can be found in the Full Paper by A. Imamura, H. Ishida, et al. on page 796.