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Epitaxial Crystallization of Insulin on an Ordered 2D Polymer Template
Author(s) -
de Poel Wester,
Elemans Johannes A. A. W.,
van Enckevort Willem J. P.,
Rowan Alan E.,
Vlieg Elias
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201805276
Subject(s) - mica , muscovite , crystallization , epitaxy , materials science , crystallography , monomer , polymer , orthorhombic crystal system , monolayer , polymerization , layer (electronics) , protein crystallization , polymer chemistry , chemical engineering , nanotechnology , chemistry , crystal structure , composite material , quartz , engineering
Two‐dimensional polymers (2DP) are a new class of materials that consist of a monolayer of ordered molecular building blocks, which have been covalently linked. One of these monomers was self‐assembled on a flat muscovite mica scaffold and subsequently the organic layer was polymerized. The resulting flat and stable 2DP layer was used as a template for protein crystallization. Crystals of insulin were epitaxially grown on the template, whereas insulin crystals grown on clean muscovite mica had a random orientation. The template was selective, considering that no epitaxially ordered crystals formed of hen egg white lysozyme, bovine serum albumin, or talin.