Premium
Cover Feature: S⋅⋅⋅Sn Tetrel Bonds in the Activation of Peroxisome Proliferator‐Activated Receptors (PPARs) by Organotin Molecules (Chem. Eur. J. 62/2018)
Author(s) -
Frontera Antonio,
Bauzá Antonio
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201805253
Subject(s) - peroxisome proliferator , molecule , covalent bond , receptor , chemistry , peroxisome , stereochemistry , biochemistry , organic chemistry
The importance and functional relevance of S⋅⋅⋅Sn tetrel‐bonding interactions in the activation of peroxisome proliferator‐activated receptors (PPARs) by organotin molecules was evidenced using a combined theoretical and Protein Data Bank analysis. In the figure, three hummingbirds carrying sulfur atoms establish tetrel‐bonding interactions with the organotin molecules that hang from the tree trunk. These molecules are anchored to the protein through the establishment of covalent S−Sn bonds. More information can be found in the Full Paper by A. Bauzá et al. on page 16576.