Premium
Cover Feature: Structural Effects of Fusicoccin upon Upregulation of 14‐3‐3‐Phospholigand Interaction and Cytotoxic Activity (Chem. Eur. J. 60/2018)
Author(s) -
Ohkanda Junko,
Kusumoto Atsushi,
Punzalan Louvy,
Masuda Ryoma,
Wang Chenyu,
Parvatkar Prakash,
Akase Dai,
Aida Misako,
Uesugi Motonari,
Higuchi Yusuke,
Kato Nobuo
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201805014
Subject(s) - fusicoccin , downregulation and upregulation , cytotoxic t cell , stereochemistry , chemistry , diterpene , cover (algebra) , glucoside , combinatorial chemistry , biochemistry , in vitro , gene , medicine , enzyme , engineering , mechanical engineering , alternative medicine , atpase , pathology
Fusicoccin , a phytotoxic diterpene glucoside, was converted to a series of antiproliferative agents for tumor cells by removing 12‐hydroxyl group semi‐synthetically. These compounds were shown to upregulate interaction of 14‐3‐3 and a phospholigand in a sequence‐specific manner. More information can be found in the Full Paper by J. Ohkanda et al. on page 16066.