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Cover Feature: RNA versus DNA G‐Quadruplex: The Origin of Increased Stability (Chem. Eur. J. 61/2018)
Author(s) -
Zaccaria Francesco,
Fonseca Guerra Célia
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201805011
Subject(s) - g quadruplex , rna , dna , electrostatics , cover (algebra) , non covalent interactions , chemistry , stability (learning theory) , quantum chemical , chemical physics , computational chemistry , nanotechnology , physics , crystallography , hydrogen bond , materials science , molecule , computer science , biochemistry , engineering , organic chemistry , mechanical engineering , machine learning , gene
G‐Quadrupex‐RNA is structurally similar to its DNA counterpart but shows higher stability. Quantum chemical (DFT‐D) calculations pinpoint the role of noncovalent interactions and better electrostatics in determining RNA‐GQs higher stabilities, focussing on the contribution of the extra ribonucleosidic 2’‐OH groups. New insight on the necessity of cations for the assembly of these structures has been given, emphasizing how they are required to overcome entropic penalty and not, like previously assumed, to minimize internal repulsion forces. More information can be found in the Full Paper by C. Fonseca Guerra and F. Zaccaria on page 16315.