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Stereoselective Sensing of l ‐ and d ‐Amino Acids: Development of a Fluorescence‐Array Based on Readily Available Chiral Phosphoric Acids
Author(s) -
OctaSmolin Frescilia,
Niemeyer Jochen
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201805003
Subject(s) - fluorescence , chemistry , stereoselectivity , phosphoric acid , amino acid , biochemistry , organic chemistry , catalysis , physics , quantum mechanics
The identification of structurally related analytes has become possible using sensor arrays, based on sets of cross‐reactive chemosensors. This work reports the use of readily available chiral phosphoric acids for the array‐based, chemo‐ and stereoselective sensing of l ‐ and d ‐amino acids. Six bis‐ and trisphosphoric acids were used in combination with Ni 2+ and Eu 3+ , resulting in a set of twelve chiral fluorescent chemosensors. This sensor‐array enables a correct classification of l ‐amino acids with 100 % accuracy, while the differentiation between l ‐ and d ‐amino acids can be achieved with 94 % accuracy. In addition, the systematic analysis of sensor contributions has allowed the use of a reduced set of seven sensors for the classification of l ‐amino acids, thus drastically reducing the amount of necessary measurements.