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Application of In Situ Product Crystallization and Related Techniques in Biocatalytic Processes
Author(s) -
Hülsewede Dennis,
Meyer LarsErik,
von Langermann Jan
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201804970
Subject(s) - bioprocess , biochemical engineering , crystallization , process engineering , process (computing) , computer science , in situ , chemistry , engineering , chemical engineering , organic chemistry , operating system
This Minireview highlights the application of crystallization as a very powerful in situ product removal (ISPR) technique in biocatalytic process design. Special emphasis is placed on its use for in situ product crystallization (ISPC) to overcome unfavorable thermodynamic reaction equilibria, inhibition, and undesired reactions. The combination of these unit operations requires an interdisciplinary perspective to find a holistic solution for the underlying bioprocess intensification approach. Representative examples of successful integrated process options are selected, presented, and assessed regarding their overall productivity and applicability. In addition, parallels to the use of adsorption as a very similar technique are drawn and similarities discussed.