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Ruthenium(IV) Intermediates in C−H Activation/Annulation by Weak O ‐Coordination
Author(s) -
Liang YuFeng,
Yang Long,
Rogge Torben,
Ackermann Lutz
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201804734
Subject(s) - ruthenium , chemistry , annulation , isocoumarins , catalysis , electrophile , benzoic acid , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry
Ruthenium(IV) complexes were identified as key intermediates of C−H/O−H activations by weak O ‐coordination. Thus, the annulations of sulfoxonium ylides by benzoic acids provided expedient access to diversely‐decorated isocoumarins with ample scope. Detailed experimental and computational studies provided strong support for a facile BIES‐C−H activation, along with cyclometalated ruthenium(IV) intermediates within a versatile ruthenium(II/IV) catalysis regime (BIES=base‐assisted internal electrophilic substitution).