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From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis
Author(s) -
Svezhentseva Ekaterina V.,
Vorotnikov Yuri A.,
Solovieva Anastasiya O.,
Pozmogova Tatia.,
Eltsov Ilia V.,
Ivanov Anton A.,
Evtushok Darya V.,
Miroshnichenko Svetlana M.,
Yanshole Vadim V.,
Eling Charlotte J.,
Adawi Ali M.,
Bouillard JeanSebastien G.,
Kuratieva Natalia V.,
Fufaeva Maria S.,
Shestopalova Lidiya V.,
Mironov Yuri V.,
Efremova Olga A.,
Shestopalov Michael A.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201804663
Subject(s) - hydrolysis , chemistry , octahedron , tungsten , cytotoxicity , toxicity , molybdenum , phototoxicity , photochemistry , inorganic chemistry , organic chemistry , biochemistry , ion , in vitro
Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water‐soluble photoluminescent octahedral tungsten cluster [{W 6 I 8 }(DMSO) 6 ](NO 3 ) 4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.