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Chiral Au I ‐ and Au III ‐Isothiourea Complexes: Synthesis, Characterization and Application
Author(s) -
Gasperini Danila,
Greenhalgh Mark D.,
Imad Rehan,
Siddiqui Shezaib,
Malik Anum,
Arshad Fizza,
Choudhary Muhammad Iqbal,
AlMajid Abdullah M.,
Cordes David B.,
Slawin Alexandra M. Z.,
Nolan Steven P.,
Smith Andrew D.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201804653
Subject(s) - enantiopure drug , catalysis , chemistry , steric effects , cationic polymerization , yield (engineering) , combinatorial chemistry , iridium , enantioselective synthesis , stereochemistry , medicinal chemistry , polymer chemistry , organic chemistry , materials science , metallurgy
During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold‐isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air‐ and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)‐isothiourea carbonyl complexes. The novel gold(I)‐ and gold(III)‐isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.