Premium
Electrochemical Synthesis of 5‐Aryl‐phenanthridin‐6‐one by Dehydrogenative N,C Bond Formation
Author(s) -
Kehl Anton,
Breising Valentina M.,
Schollmeyer Dieter,
Waldvogel Siegfried R.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201804638
Subject(s) - aryl , electrochemistry , chemistry , combinatorial chemistry , organic chemistry , alkyl , electrode
Currently, the general synthesis of 5‐aryl‐phenanthridin‐6‐ones relies on the involvement of metal catalysis. Despite the urgent demand for green alternatives, avoiding synthetic routes that require transition metals for key roles is still challenging. Electrochemical efforts employing a constant potential protocol in divided cells revealed a possible alternative to the catalytic approach. A constant current protocol, undivided cells, and a remarkably low supporting electrolyte concentration enable a novel access to N ‐aryl‐phenanthridin‐6‐ones by anodic N,C bond formation using directly generated amidyl radicals. Easy accessible starting materials, a broad scope of applicable functional groups, good yields, and a very simple set‐up are the benefits of this sustainable method.