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A Unified Approach to Customized Chiral Carbon‐Bridged ansa ‐Metallocenes
Author(s) -
Wiesler Stefan,
Bau Michael A.,
Younas Sara L.,
Luu HieuTrinh,
Kratzert Daniel,
Streuff Jan
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201804497
Subject(s) - metallocene , ligand (biochemistry) , chirality (physics) , catalysis , combinatorial chemistry , planar chirality , selectivity , stereoselectivity , materials science , modular design , enantioselective synthesis , stereochemistry , chemistry , organic chemistry , polymerization , physics , computer science , chiral symmetry breaking , symmetry breaking , biochemistry , receptor , quantum mechanics , nambu–jona lasinio model , polymer , operating system
Chiral ansa ‐metallocenes are privileged catalysts for a range of stereoselective transformations. Their synthesis, however, has remained a tremendous challenge, which has prevented a broad and systematic exploration for applications in synthesis and catalysis. A modular approach to such ansa ‐metallocenes that enables a facile modification of the ring substitution and the ligand bridge, as well as the introduction of various core metals, is described. The complexes were formed with good rac ‐selectivity and could be isolated with high purity. The strength of the approach was demonstrated by the synthesis of several new and previously known complexes, including a unique helical chiral ansa ‐metallocene. Using a chiral ligand, a moderate central‐to‐planar chirality transfer was observed.