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Cover Feature: Molecular Encapsulation Inside Microtubules Based on Tau‐Derived Peptides (Chem. Eur. J. 56/2018)
Author(s) -
Inaba Hiroshi,
Yamamoto Takahisa,
Kabir Arif Md. Rashedul,
Kakugo Akira,
Sada Kazuki,
Matsuura Kazunori
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201804321
Subject(s) - microtubule , peptide , tubulin , biophysics , chemistry , nanotechnology , materials science , microbiology and biotechnology , biochemistry , biology
A methodology for molecular encapsulation inside hollow microtubules has been developed based on the peptide design. A peptide derived from Tau protein binds to a pocket of tubulin (component of microtubules), which is located at the inner surface of the microtubules. The Tau‐derived peptide can be used to encapsulate exogenous cargos inside microtubules. The cover image shows the peptide—gold nanoparticle conjugates bound to tubulin and subsequently introduced to the inside of the microtubules. More information can be found in the Full Paper by H. Inaba, K. Matsuura, et al. on page 14958.