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Synthesis of (±)‐Merrilactone A by a Desymmetrization Strategy
Author(s) -
Liu Wentan,
Wang Bo
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201804195
Subject(s) - desymmetrization , hydroacylation , allene , intramolecular force , chemistry , stereochemistry , catalysis , enantioselective synthesis , organic chemistry , aldehyde
A concise synthesis of (±)‐merrilactone A has been accomplished featuring desymmetrization of a C s ‐symmetric dilactone, Rh I ‐catalyzed intramolecular hydroacylation of a 4‐alkynal, and Ti III ‐mediated reductive radical cyclization of epoxy‐allene.