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Iodine(III)‐Mediated Electrochemical Trifluoroethoxylactonisation: Rational Reaction Optimisation and Prediction of Mediator Activity
Author(s) -
Möckel Robert,
Babaoglu Emre,
Hilt Gerhard
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201804152
Subject(s) - electrochemistry , iodine , multivariate statistics , compatibility (geochemistry) , chemistry , combinatorial chemistry , chemical engineering , mathematics , organic chemistry , electrode , engineering , statistics
A new electrochemical iodine(III)‐mediated cyclisation reaction for the synthesis of 4‐(2,2,2‐trifluoroethoxy)isochroman‐1‐ones is presented. Based on this reaction design of experiments and multivariate linear regression analysis were used to demonstrate their first application in an electrochemical reaction. The broad applicability of these reaction conditions could be shown by a range of substrates and an extensive compatibility test.