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Exploring Atypical Fluorine–Hydrogen Bonds and Their Effects on Nucleoside Conformations
Author(s) -
O'Reilly Daniel,
Stein Robin S.,
Patrascu Mihai Burai,
Jana Sunit Kumar,
Kurian Jerry,
Moitessier Nicolas,
Damha Masad J.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201803940
Subject(s) - hydrogen bond , chemistry , fluorine , natural bond orbital , supramolecular chemistry , computational chemistry , crystallography , nuclear magnetic resonance spectroscopy , stereochemistry , molecule , organic chemistry , density functional theory , crystal structure
The ability of fluorine to serve as a hydrogen‐bond acceptor has been debated for many years. Short fluorine–hydrogen contacts are thought to play a key role in stabilizing some complex supramolecular systems. To directly probe the existence of fluorine–hydrogen bonds, we have performed NMR spectroscopy and computational modeling on a series of C2′‐fluorinated nucleosides. Specifically, quantum mechanics/molecular mechanics (QM/MM) analysis and [ 19 F, 1 H] HMBC NMR experiments provided direct evidence for a C−H⋅⋅⋅F hydrogen bond in a 2′‐F,4′‐C‐α‐alkyl‐ribonucleoside analogue. This interaction was also supported by QTAIM and NBO analyses, which confirmed a bond critical point for the C−H⋅⋅⋅F interaction (0.74 kcal mol −1 ). In contrast, although conformational analysis and NMR experiments of 2′‐deoxy‐2′‐fluoro‐arabinonucleosides indicated a close proximity between the 2′‐fluorine and the H6/8 protons of the nucleobase, molecular simulations did not provide evidence for a C−H⋅⋅⋅F hydrogen bond.