Premium
Short, Tin‐Free Synthesis of All Three Inthomycins
Author(s) -
Kumar Manjeet,
Bromhead Liam,
Anderson Zoe,
Overy Alistair,
Burton Jonathan W.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201803794
Subject(s) - enantioselective synthesis , sonogashira coupling , aldol reaction , combinatorial chemistry , tin , stereochemistry , chemistry , organic chemistry , catalysis , palladium
The inthomycins are a family of structurally and biologically rich natural products isolated from Streptomyces species. Herein the implementation of a modular synthetic route is reported that has enabled the enantioselective synthesis of all three inthomycins. Key steps include Suzuki and Sonogashira cross‐couplings and an enantioselective Kiyooka aldol reaction.