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Cover Feature: Molecular Tweezers with Additional Recognition Sites (Chem. Eur. J. 44/2018)
Author(s) -
Heid Christian,
Sowislok Andrea,
Schaller Torsten,
Niemeyer Felix,
Klärner FrankGerrit,
Schrader Thomas
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201803759
Subject(s) - molecular tweezers , optical tweezers , molecular recognition , tweezers , feature (linguistics) , chemistry , cover (algebra) , click chemistry , computational biology , nanotechnology , computer science , biophysics , combinatorial chemistry , materials science , biology , molecule , physics , engineering , philosophy , supramolecular chemistry , organic chemistry , optics , mechanical engineering , linguistics
Molecular tweezers selectively include lysine and arginine inside their cavities, leading to fascinating biological properties: they prevent pathologic protein aggregation and interfere with protein–protein interactions. This work presents two methods showing how additional arms can be attached to the tweezer body, either with trichloroacetonitrile or with phosphoramidites. If these arms carry terminal alkynes, click chemistry may introduce additional recognition sites and labels for a wide range of applications. More information can be found in the Full Paper by T. Schrader et al. on page 11332.