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Photodynamic Activity of Fullerene Derivatives Solubilized in Water by Natural‐Product‐Based Solubilizing Agents
Author(s) -
Antoku Daiki,
Sugikawa Kouta,
Ikeda Atsushi
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201803657
Subject(s) - fullerene , photodynamic therapy , photosensitizer , chemistry , photochemistry , ultraviolet , liposome , combinatorial chemistry , molecule , natural product , organic chemistry , materials science , optoelectronics , biochemistry
Water‐soluble fullerenes prepared by using solubilizing agents based on natural products are promising photosensitizers for photodynamic therapy. Cyclodextrin, β‐1,3‐glucan, lysozyme, and liposomes can stably solubilize not only C 60 and C 70 , but also some C 60 derivatives in water. To improve the solubilities of fullerenes, specific methods have been developed for each solubilizing agent. Water‐soluble C 60 and C 70 exhibit photoinduced cytotoxicity under near‐ultraviolet irradiation, but not at wavelengths over 600 nm, which are the appropriate wavelengths for photodynamic therapy. However, dyad complexes of solubilized C 60 derivatives combined with light‐harvesting antenna molecules improve the photoinduced cytotoxicities at wavelengths over 600 nm. Furthermore, controlling the fullerene and antenna molecule positions within the solubilizing agents affects the performance of the photosensitizer.