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Front Cover: Combination of Aryl Diselenides/Hydrogen Peroxide and Carbon‐Nanotube/Rhodium Nanohybrids for Naphthol Oxidation: An Efficient Route towards Trypanocidal Quinones (Chem. Eur. J. 57/2018)
Author(s) -
de Carvalho Renato L.,
Jardim Guilherme A. M.,
Santos Augusto C. C.,
Araujo Maria H.,
Oliveira Willian X. C.,
Bombaça Ana Cristina S.,
MennaBarreto Rubem F. S.,
Gopi Elumalai,
Gravel Edmond,
Doris Eric,
da Silva Júnior Eufrânio N.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201803537
Subject(s) - rhodium , aryl , hydrogen peroxide , carbon nanotube , catalysis , ring (chemistry) , chemistry , combinatorial chemistry , organic chemistry , nanotechnology , materials science , alkyl
A combination of aryl diselenides/hydrogen peroxide and carbon‐nanotube/rhodium nanohybrids for naphthol oxidation is reported. The synthesis of 1,4‐naphthoquinones and evaluation of their relevant trypanocidal activity was accomplished in an elegant manner. Several benzenoid (A‐ring)‐substituted quinones are described, prepared in moderate to high yields. The synthesis of A‐ring‐substituted 1,4‐naphthoquinones is a challenge. The contribution of carbon‐nanotube/Rh as co‐catalyst in this process was investigated and, in some cases, yields were improved. This method provides an efficient and versatile alternative for preparing A‐ring‐modified naphthoquinonoid compounds with relevant biological profiles. More information can be found in the Full Paper by E. Doris, E. N. da Silva Júnior, et al. on page 15227.