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Front Cover: Alkyl Radical Generation by an Intramolecular Homolytic Substitution Reaction between Iron(II) and Trialkylsulfonium Groups (Chem. Eur. J. 43/2018)
Author(s) -
Jungen Stefan,
Chen Peter
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201803535
Subject(s) - chemistry , homolysis , sulfonium , electrospray ionization , radical , alkyl , medicinal chemistry , intramolecular force , substitution reaction , dissociation (chemistry) , photochemistry , radical ion , leaving group , mass spectrometry , stereochemistry , organic chemistry , ion , catalysis , salt (chemistry) , chromatography
Reductive cleavage of trialkylsulfonium groups by iron(II) via homolytic substitution reactions has been observed in electrospray ionization mass spectrometry (ESI‐MS) studies upon collision induced dissociation (CID). In these reactions iron(II) acts as a “metalloradical” attacking the sulfonium group as a one‐electron donor, leading to alkyl radical formation. Interestingly, this process is closely related to the putative radical generation step in radical S ‐adenosyl methionine enzymes. More information can be found in the Full Paper by P. Chen and S. Jungen on page 11008.