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Reversible Photocontrol of DNA Melting by Visible‐Light‐Responsive F4‐Coordinated Azobenzene Compounds
Author(s) -
Dudek Marta,
Deiana Marco,
Pokladek Ziemowit,
Pawlik Krzysztof,
Matczyszyn Katarzyna
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201803529
Subject(s) - azobenzene , visible spectrum , dna , photochromism , photochemistry , materials science , chemistry , optoelectronics , polymer , organic chemistry , biochemistry
Spatiotemporal control over the regulation of intra‐ and intermolecular motions in naturally occurring systems is systematically studied to expand the toolbox of mechanical operations in multicomponent nanoarchitectures. DNA is ideally suited for programming light‐powered processes that are based on a minimalist molecular design. Here, the noncovalent incorporation of bistable photoswitches into B‐like DNA moieties is shown to trigger the thermal transition midpoint of the duplexes by converting visible light into directed mechanical work by orchestrating the collective actions of the photoresponsive chromophores and the host DNA nanostructures. Besides its practical applications, the resulting hybrid nanosystem bears unique features of modulability, biocompatibility, reversibility, and addressability, which are key components for developing molecular photon‐controlled programmed materials.