Photocatalyzed Intermolecular Aminodifluoromethylphosphonation of Alkenes: Facile Synthesis of α,α‐Difluoro‐γ‐aminophosphonates

Abstract An efficient and practical method for the synthesis of α,α‐difluoro‐γ‐aminophosphonates through photocatalyzed intermolecular aminodifluoromethylphosphonation of alkenes has been developed. In this reaction, difluoromethylphosphonate is used as an important fluorinated reagent. Furthermore, the mild reaction conditions, simple operation, and broad substrate scope make this protocol very practical and attractive. The derivatization reaction in the synthesis of difluoromethylphosphonated chiral binaphthylamine ligands and α,α‐difluoro‐γ‐aminophosphoric acid highlight the applicability of this method.