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Front Cover: Rational Design of a 3 10 ‐Helical PIP‐Box Mimetic Targeting PCNA, the Human Sliding Clamp (Chem. Eur. J. 44/2018)
Author(s) -
Wegener Kate L.,
McGrath Amy E.,
Dixon Nicholas E.,
Oakley Aaron J.,
Scanlon Denis B.,
Abell Andrew D.,
Bruning John B.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201803279
Subject(s) - proliferating cell nuclear antigen , dna , peptide , chemistry , microbiology and biotechnology , biophysics , biology , biochemistry
PCNA Space Odyssey : PCNA (the human sliding clamp) is depicted as a protein surface representation (colored in grey) in complex with the first p21‐derived peptide mimetic inhibitor (shown as sticks colored by element). Protein amino acids on the surface of PCNA within 4 Å of the peptide mimetic are colored in purple. The comet highlights the emptiness of the PCNA inner channel which is usually occupied by DNA; the mimetic should block PCNA's ability to be loaded onto DNA. More information can be found in the Full Paper by J. B. Bruning, et al. on page 11325.