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Brønsted Base Assisted Photoredox Catalysis: Proton Coupled Electron Transfer for Remote C−C Bond Formation via Amidyl Radicals
Author(s) -
Jia Jiaqi,
Ho Yee Ann,
Bülow Raoul F.,
Rueping Magnus
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201802907
Subject(s) - photoredox catalysis , radical , chemistry , alkene , intramolecular force , photochemistry , intermolecular force , alkyne , electron transfer , catalysis , functional group , brønsted–lowry acid–base theory , combinatorial chemistry , photocatalysis , stereochemistry , organic chemistry , molecule , polymer
The synthesis of alkyne‐ and alkene‐decorated lactams has been achieved through a photoredox‐initiated radical cascade reaction. The developed Brønsted base assisted, photoredox‐catalyzed, intramolecular 5‐ exo ‐ trig cyclization/intermolecular radical addition/elimination reaction provides facile access to functionalized γ‐lactams, with good functional group tolerance and high yields.