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Cover Feature: Self‐assembly of Fluorescent Dehydroberberine Enhances Mitochondria‐Dependent Antitumor Efficacy (Chem. Eur. J. 39/2018)
Author(s) -
An Ruibing,
Gu Zhanni,
Sun Haifeng,
Hu Yuxuan,
Yan Runqi,
Ye Deju,
Liu Hong
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201802840
Subject(s) - fluorescence , mitochondrion , chemistry , tetraphenylborate , nanoparticle , biophysics , cancer therapy , molecule , combinatorial chemistry , cancer , biochemistry , nanotechnology , ion , materials science , biology , organic chemistry , physics , quantum mechanics , genetics
A fluorescent mitochondria‐targeting dehydroberberine (DH‐BBR) that could form organic nanoparticles by a lipophilic anion tetraphenylborate (TPB)‐mediated self‐assembly process was developed. The self‐assembled nanoparticles could remarkably enhance the uptake of DH‐BBR into tumor cells, induce significant mitochondrial dysfunction, and ultimately inhibit tumor growth in living mice. This study demonstrated the great potential of using self‐assembly approach to engineer mitochondria‐targeting small molecules for improved cancer therapy. More information can be found in the Full Paper by D. Ye, H. Liu, et al. on page 9812.