Premium
Supramolecular Coordination Cages for Asymmetric Catalysis
Author(s) -
Tan Chunxia,
Chu Dandan,
Tang Xianhui,
Liu Yan,
Xuan Weimin,
Cui Yong
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201802817
Subject(s) - supramolecular chemistry , supramolecular catalysis , enantioselective synthesis , nanotechnology , rational design , chirality (physics) , supramolecular chirality , catalysis , coordination complex , combinatorial chemistry , chemistry , substrate (aquarium) , materials science , organic chemistry , metal , molecule , physics , biology , ecology , chiral symmetry breaking , quantum mechanics , quark , nambu–jona lasinio model
Abstract Inspired by the high efficiency and specificity of enzymes in living systems, the development of artificial catalysts intrinsic to the key features of enzyme has emerged as an active field. Recent advances in supramolecular chemistry have shown that supramolecular coordination cages, built from non‐covalent coordination bonds, offer a diverse platform for enzyme mimics. Their inherent confined cavity, analogous to the binding pocket of an enzyme, and the facile tunability of building blocks are essential for substrate recognition, transition‐state stabilization, and product release. In particular, the combination of chirality with supramolecular coordination cages will undoubtedly create an asymmetric microenvironment for promoting enantioselective transformation, thus providing not only a way to make synthetically useful asymmetric catalysts, but also a model to gain a better understanding for the fundamental principles of enzymatic catalysis in a chiral environment. The focus here is on recent progress of supramolecular coordination cages for asymmetric catalysis, and based on how supramolecular coordination cages function as reaction vessels, three approaches have been demonstrated. The aim of this review is to offer researchers general guidance and insight into the rational design of sophisticated cage containers for asymmetric catalysis.